Research Scientist (Chemical Biology)

Orionis Biosciences is a pioneering biotech company focused on revolutionizing cancer treatment through cutting-edge innovation. Guided by a technology-driven vision, we integrate small molecule screening platforms with proprietary protein technology systems to develop next-generation medicines. Founded in 2015, we’ve grown rapidly, with offices and research hubs in both Ghent (Belgium) and Boston (USA). To strengthen our Chemical Biology team in Ghent, we’re looking for a motivated RESEARCH SCIENTIST (Phd) with proven experience in cell biology and protein interaction technologies.  

Your role:  
As a Research Scientist at Orionis, you will play a key role in multiple small-molecule discovery projects, including both in-house initiatives and collaborative programs with external partners. You will oversee various aspects of these projects throughout the entire project lifecycle, such as planning, generating and analyzing results, and reporting results. Your primary focus will be on downstream hit validation using biochemical, biophysical, and functional assays. You will work closely with the Chemical Biology team to design, optimize, and troubleshoot these experiments while advancing our drug discovery efforts.  

Your profile: 
To excel in this role, we’re looking for someone who brings the following experience and skills: 

• A PhD in a relevant life sciences discipline.
• A strong hands-on experience in, and understanding of, designing, developing and troubleshooting protein-protein and small-molecule protein interaction assays.
• Relevant experience in small molecule hit discovery campaigns.
• Proficient in a wide range of biochemical and/or biophysical assay technologies (e.g., HTRF, NanoBRET, Lumit, AlphaScreen, etc.).
• Experience working with CRO’s on protein production, biophysical assays, and related activities is strongly preferred.
• Excellent written and verbal communication skills in English. Preferably, you also have a good knowledge of Dutch.
• A highly collaborative and organized way of working.
• Detail-oriented, efficient and able to thrive under time-sensitive conditions.
• A proactive mindset, self-motivated, enthusiastic and a genuine passion for innovation. 

What we offer :
At Orionis Biosciences, you will be part of a collaborative team within a dynamic, ambitious and fast-growing organization dedicated to transforming the landscape of cancer treatment. We offer a fulltime contract with a competitive salary tailored to your experience, qualifications and background. In addition, you get a chance to work on diverse and impactful projects alongside a team of experienced professionals. 

If you are excited to contribute to innovative cancer research and enjoy working in a collaborative biotech environment, we would be happy to hear from you. Please send your CV (clearly indicating your relevant experience) and motivation letter to HR-be@orionisbio.com.  Please note that all applications will be processed during the week of January 5th, 2026.